TNF/LIGH家族成员在黏膜的动态平衡和重塑中的作用
2021-11-29 07:03:48 来源: 金华白癜风医院 咨询医生
Immunol Rev 2011 No244(1):75-84. [IF:13.462]The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling.Zhu M , Fu YX .Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA.
杭州中国科学院生物物理研究所,中国科学院,感染与特异性重点研究团队,耶鲁大学,病理学委员会特异性学部
AbstractSummary: Lymph nodes (LNs) maintain active homeostasis at steady state. However, in response to changes in the local environment, such as local infection, cancer, vaccination, and autoimmune disease, dramatic remodeling of LN occurs. This remodeling includes changes in size, lymph and blood flow, immune cell trafficking and cellularity, lymphatic and blood vessel growth and activation, as well as microarchitecture. Therefore, inflammatory conditions often lead to enlarged nodes; after local inflammation resolves, LNs actively regress in size and return to steady state. Remodeling of lymphatic vessels (LVs) and blood vessels (BVs) during both the expansion and regression phases are key steps in controlling LN size as well as function. The cells, membrane-associated molecules, and soluble cytokines that are essential for LV and BV homeostasis as well as dynamic changes in the expansion and regression phases he not been well defined. Understanding the underlying cellular and molecular mechanisms behind LN remodeling would help us to better control undesired immune responses (e.g. inflammation and autoimmune diseases) or promote desired responses (e.g. antitumor immunity and vaccination). In this review, we focus on how the closely related tumor necrosis factor (TNF) members: LIGHT (TNFSF14), lymphotoxin-αβ, and TNF-α contribute to the remodeling of LNs at various stages of inflammation.
编辑: lizexiu上一页:白癜风的预防方法详述
- 2022-05-02白癜风的病因侵害
- 2022-04-28补骨脂功效与抑制作用
- 2022-04-25桥本氏甲状腺炎的病因是这样的——为什么他们的免疫力会错误地攻击甲状腺
- 2022-04-20咳嗽的病因是什么?
- 2022-04-12注射激素会导致外周色素减少和萎缩
- 2022-04-04原发性小肠淋巴管扩张症一例
- 青少年白癜风的病因治白癜风需要哪些调节
- 诊断白斑是白癜风的方式是什么
- 细数白癜风危害白癫风日常如何保健
- 神经性皮炎白癜风的特点
- 白癜风遮盖产品有多大的用处
- 白癜风的颜色来判断病情
- 白癜风的主要诱因
- 白癜风的一系列知识
- 白癜风治疗方法和相关药物
- 白癜风早期有什么症状
- 白癜风愈后要如何护理谨记白癜风患者的饮食原则
- 白癜风患者能吃海鲜吗白癜风患者能吃辣椒吗
- 白癜风患者怎样才能预防遗传
- 白癜风患者可做哪些运动运动时注意6大事项
- 白癜风常见的五大类型关于白癜风护理的误区你中了哪些
- 白癜风复发的危害大应做好3大措施来预防
- 白癜风光化学和免疫法
- 男性得了白癜风怎样护理
- 治疗白癜风路上的这些坑不要再入了
- 检查白癜风一次花费多少钱
- 早期儿童白癜风的症状表现白癜风的预防方法
- 患者问如何利用核桃青皮治疗白癜风
- 平时白癜风患者要注意哪些
- 寒假将至治好白癜风比补课更重要
- 如何挑选好的治疗白癜风的医院治疗白癜风前的注意事项
- 头部患了白癜风该怎么办
- 哪些药白癜风患者应该慎用
- 哪些因素引起夏季白癜风复发呢
- 儿童白癜风护理对孩子健康很关键
- 从内到外加把针老中医治疗白癜风有绝招
- 为什么小零食会诱发儿童白癜风呢
- 10年以上的白癜风是晚期吗晚期白癜风能治好吗
- 长期吃黑芝麻的人能治好白发吗?
- 注射激素会导致外周色素减少和萎缩
- 治疗白癜风的方法 牢记这些治疗白癜风更省钱
- 婴儿身上的白斑是白癜风吗?
- 白癜风光疗有很多方法 因地制宜教你选择
- 疾病新知:毛囊性白癜风
- 17 年度经验:随访胡须斑秃预后
- 病例报告:水浴 PUVA 治疗皮下环状肉芽肿